Advances in Catalytic and Metal-Free Synthesis of Benzothiadiazine 1-Oxides, 1,1-Dioxides, and 1-Imines.

Authors

Irsa Kainat, Muhammad Khuzaifa, Yuqing Cao, Qingle Zeng

Published in

Chemical record (New York, N.Y.). Pages e70198. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

Benzothiadiazine derivatives are an important class of sulfur-nitrogen heterocycles widely recognized in medicinal chemistry for their structural flexibility and varied biological effects. This review highlights recent developments in the synthesis of benzothiadiazine-derived compounds, including 1-oxides, 1,1-dioxides, and newly explored 1-imines. It focuses on contemporary synthetic methods, including transition-metal catalysis, cascade reactions, heterogeneous catalysis (polyoxometalates and metal-organic frameworks), and environmentally friendly metal-free approaches. The review discusses the scope, effectiveness, and limitations of these techniques, alongside their key biological applications in cardiovascular, anticancer, antiviral, and neurological fields. Additionally, it underscores existing challenges and future research directions to foster the development of more efficient and sustainable synthetic strategies.

PMID:
42319809
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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