Factor selection in configurational comparative analysis - guidance for implementation researchers.

Authors

Laura Caci, Kathrin Blum, Lauren Clack, Bianca Albers

Published in

Implementation science communications. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

Configurational comparative methods (CCMs) are designed for the systematic comparison of case data to identify necessary and sufficient conditions for an outcome. The complex interplay of contextual factors, implementation strategies, and intervention components makes CCMs particularly suitable for implementation studies. Factor selection is a stage in CCMs during which researchers determine a limited set of variables of interest for analysis. Guidance that helps implementation researchers to select a manageable set of factors from a plethora of potentially interesting components is warranted but lacking, especially, for pre-data collection. We provide such guidance with an emphasis on (1) intentional data collection, and (2) broad engagement of interest-holders across different stages of factor selection.
Our suggested approach consists of four stages: (1) factor identification, (2) factor prioritization, (3) factor determination, and (4) factor operationalization. Throughout these stages, we highlight opportunities for engaging interest-holders.
We illustrate all stages using experience from a multinational hybrid implementation-effectiveness trial in the field of infection prevention. First, we conducted a systematic review to identify potentially relevant factors. Second, we applied the Nominal Group Technique in meetings with interest-holders to prioritize previously identified factors. Third, we conducted two project workshops to decide on a final set of factors. Fourth, we operationalized factors into measurable units and assessed them using qualitative and quantitative methods.
We present a methodology and applied case example for pre-data collection factor selection for CCMs. The proposed method comprises four stages, each requiring implementation researchers to balance scientific rigor with pragmatism, while ensuring meaningful engagement of interest-holders. This guidance closes a gap in existing recommendations, which have primarily focused on factor selection during data analysis. Making CCMs more accessible and increasing their use should remain a central priority in implementation science.

PMID:
42321917
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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