Immunomodulatory role and therapeutic potential of thrombospondin-1 during infectious diseases and autoimmunity.

Authors

Francisca Román, Aillairlyn Jara, Agnes Jara-Collao, Felipe Novoa, Cynthia Moreno-Quidecoy, Valentina Chavez, Fernanda Urzúa, Daniel Moreno, Susan M Bueno, Pablo A González, Alexis M Kalergis, Hernán F Peñaloza

Published in

BMC biology. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

Infectious diseases and autoimmunity are leading causes of mortality worldwide. The lack of vaccines and resistance to current treatments by microbes highlight the importance of developing novel therapeutics. Similarly, treatments for autoimmune diseases are limited and require improved approaches. Identifying relevant proteins involved in host defense and tolerance to self-antigens is key to designing novel therapeutic strategies. Thrombospondin-1 (TSP-1) is a host glycoprotein involved in host defense and inflammation. Here, we analyze how TSP-1 interacts with different ligands involved in immunity. Then, we discuss the roles of TSP-1 in infection and autoimmunity to finally examine the therapeutic potential of TSP-1.

PMID:
42321755
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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