Authors
Mathias Holmsgaard Eskesen, Alexander Djupnes Fuglkjær, Tarec Christoffer El-Galaly, Paw Jensen, Izabela Ewa Nielsen, Laurids Østergaard Poulsen, Mikkel Runason Simonsen, Kirstine Kobberøe Søgaard
Published in
European journal of haematology. Jun 19, 2026. Epub Jun 19, 2026.
Abstract
Bloodstream infections remain a major cause of mortality among cancer patients. Pathogen surveillance and risk stratification tools are key to improved management. This study describes trends in causative pathogens and explores risk factors for positive blood cultures (PBCs) and post-infection mortality in cancer patients.
We performed a cohort study of patients diagnosed with a B-cell malignancy in the North Denmark Region between 2013 and 2022, linking cancer registry data to health records. Causative pathogens were described. LASSO regression was used to select variables associated with PBCs and post-infection mortality. Odds ratios were estimated by univariate analyses.
Among 1592 patients with B-cell malignancies, 341 patients (21.4%) had at least one PBC, yielding 484 PBCs. We observed a shift from Gram-positive to Gram-negative dominance, driven by an increased frequency of the most common pathogen Escherichia coli (24.8%). Patients with neutropenia, elevated CRP, sepsis, hypotension, or kidney failure had a higher risk of a PBC. Advanced age, kidney failure, and sepsis were all associated with 30- and 90-day post-infection mortality.
Routinely available parameters obtained at time of admission were associated with blood culture positivity and mortality. Our findings support the rationale for developing predictive models to individualise infection management.
PMID:
42321020
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 1
- Comments 0