Synthesis of oleanonic acid derivatives and evaluation of their biological activities.

Authors

Zareena Kiran, Sabira Begum, Sara Sara, Bina S Siddiqui, Talea Sana, Syed Tahir Ali, Hafiz Nadeem Khan, Saima Rasheed, M Iqbal Choudhary, Sammer Yousuf, Memoona Bibi, Ayaz Ahmed, Erum Iqbal, Mehreen Lateef

Published in

Natural product research. Pages 1-11. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

In the present study, oleanolic acid was oxidised to oleanonic acid of which different derivatives were prepared and screened for their nematicidal, antiglycation, antioxidant, urease inhibition, lung cancer (NCl-H460), oral cancer (Cal-27), HeLa cell line, NIH-3T3 cells, antibacterial, and antifungal activities. Several compounds showed strong mortality against root knot nematode (Meloidogyne incognita) at 0.125% concentration after 72 h. These compounds showed moderate to strong antiglycation activity. Potent urease inhibition activity was observed for compounds 10 and 11 (IC₅₀ 15.2, 19.5 µM, respectively).

PMID:
42322099
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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