Design, Synthesis, and Biological Evaluation of Novel N-Acyl Sulfonohydrazides Derived From β-Hydroxy Esters: Anticancer, Antioxidant, and Antimicrobial Activities.

Authors

Belma Hasdemir, Tülay Yıldız, Hasniye Yaşa, Hatice Başpınar Küçük, Emel Mataracı Kara, Sümbül Yıldırım, Fatih Kocabaş, Ziya Can

Published in

Chemical biology & drug design. Volume 107. Issue 6. Pages e70344.

Abstract

In this study, a series of novel N-acyl sulfonohydrazides 6a-r derived from β-hydroxy esters was synthesized, and their structures were confirmed through spectroscopic characterization, including FT-IR, ¹H NMR, ¹³C NMR, and HRMS analyses. The anticancer properties of the synthesized compounds were investigated, along with a complementary study evaluating their antioxidant and antimicrobial properties. The cytotoxicity screening against HCT116 and PANC1 cancer cell lines revealed generally low antiproliferative effects; however, compounds 6c and 6e demonstrated relatively higher pro-apoptotic potential in HCT116 cells compared to the other compounds. In assays evaluating antioxidant capacity, utilizing both CUPRAC and DPPH methods, all synthesized compounds exhibited activity ranging from moderate to good. Notably, compound 6l demonstrated the strongest antioxidant performance with TEAC = 1.34 and IC₅₀ = 0.084 ± 0.003 mmol L^-1. Furthermore, among the tested compounds, 6a, 6b, and 6d displayed good antibacterial activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 19.53 μg/mL.

PMID:
42322066
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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