Regio-, Stereo-, and Enantioselective C(sp³)─H Monofluoroalkenylation via Photo-HAT/Nickel Dual Catalysis.

Authors

Yate Chen, Chengbing Yang, Zhaojing Xu, Zidong Liang, Yifan Xu, Wangqing Kong, Huailong Teng

Published in

Angewandte Chemie (International ed. in English). Pages e1226201. Jun 20, 2026. Epub Jun 20, 2026.

Abstract

Stereoselective functionalization of C(sp³)─H bonds in hydrocarbons constitutes a revolutionary strategy for accessing high-value chiral molecules. Despite remarkable advances in this field, enantioselective C(sp³)-H monofluoroalkenylation remains unexplored to date. Herein, we report the first regio-, stereo-, and enantioselective benzylic C(sp³)─H monofluoroalkenylation, enabled by a decatungstate-mediated hydrogen atom transfer (HAT)/nickel dual-catalytic system. This protocol utilizes inexpensive, readily available hydrocarbons and easily accessible gem-difluoroalkenes as starting materials, delivering a broad array of structurally diverse (E)-monofluoroalkenes bearing stereogenic allylic centers, versatile building blocks in synthetic chemistry.

PMID:
42322156
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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