Local Mitochondrial Growth Initiated by Femtosecond Laser-Evoked Ca²⁺ Signaling.

Authors

Bingyi Li, Zichuan Tang, Hao He

Published in

Journal of biophotonics. Volume 19. Issue 6. Pages e70313.

Abstract

Mitochondrial structural remodeling is closely coupled to intracellular Ca²⁺ signaling, and precise spatiotemporal control of this process is critical for understanding mitochondrial physiology. Here, we report an optical approach based on femtoSOC (femtosecond laser-controlled store-operated calcium channel) activation to induce localized Ca²⁺ influx and trigger region-specific mitochondrial growth in living cells. The Ca²⁺-regulated mitochondrial growth relies on MCU-dependent Ca²⁺ uptake and OPA1-mediated fusion but is not primarily mediated by the AMPK/CaMKKβ pathway. This study provides a minimally invasive strategy for precise optical control of mitochondrial dynamics and reveals an AMPK-distinct pathway linking localized Ca²⁺ signaling to mitochondrial structural remodeling.

PMID:
42324068
Bibliographic data and abstract were imported from PubMed on 22 Jun 2026.

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