The Heterogeneity of B Cells Potentially Contributes to Metastasis of Clear Cell Renal Cell Carcinomas.

Authors

Yuanhong Chen, Chun Guo, Shaoang Huang, Caixia Ling, Wenxian Lin, Zhengfang Liang, Jingjie Zhao, Lingzhang Meng, Yulian Tang, Kun Ye

Published in

Cancer investigation. Pages 1-14. Jun 21, 2026. Epub Jun 21, 2026.

Abstract

Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated.
Addressing the formidable challenge of metastasis suppression in ccRCC treatment.
Use scRNA-seq analysis and immunofluorescent imaging to categorize B cells into sub-clusters based on distinct gene expression profiles.
Identify two significant B cell subpopulations, B cell (HLA-DRA) and B cell (FKBP11); show the upregulation of six genes (DERL3, FKBP11, MZB1, TNFSF13B, MYO9B, and ACAP1) in infiltrating B lymphocytes associated with poor prognosis of ccRCC; find that B cell (HLA-DRA) displays a noteworthy association with ccRCC metastasis and demonstrates relevance to tumor immunity across diverse cancers.
The heterogeneity within B-cell subpopulations may substantially contribute to the metastatic potential of clear cell renal cell carcinoma. The findings provide insights into targeted interventions and improved clinical outcomes.

PMID:
42324780
Bibliographic data and abstract were imported from PubMed on 22 Jun 2026.

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