The Multiple Sclerosis Severity Allele rs10191329^A and Cognitive Function: A UK Biobank Study.

Authors

Ioanna Zimianiti, Sheena Waters, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M Jacobs

Published in

Annals of clinical and translational neurology. Jun 22, 2026. Epub Jun 22, 2026.

Abstract

The genome-wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329^A to long-term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329^A might influence cognition in other neurological diseases and healthy controls. We explored the relationship between rs10191329^A and cognition using reaction time, fluid intelligence, and prospective memory tests in the UK Biobank. We observed weak but directionally consistent associations between rs10191329^A and poorer cognition in controls, with similar but non-significant trends in Multiple Sclerosis, Parkinson's disease, and dementia. Our results support the hypothesis that rs10191329^A might affect multiple sclerosis outcomes by affecting brain health.

PMID:
42324924
Bibliographic data and abstract were imported from PubMed on 22 Jun 2026.

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