Authors
Lanqing Cui, Yun Li, Lingyun Ma, Huimin Ma, Jingxian Yang, Yanan Tan, Chunyue Ge, Dong Li, Yi Wang, Xinying Yang, Xiaoyi Liu, Ronghua Geng, Shumei Liu, Xiangyan Li, Bo Zheng
Published in
Frontiers in cellular and infection microbiology. Volume 16. Pages 1730782. Epub Jun 04, 2026.
Abstract
To investigate the antibacterial susceptibility and molecular characteristics of vancomycin resistant enterococci (VRE) isolated from 9 hospitals in Beijing from November 2021 to October 2022.
The susceptibilities to 17 antibacteria agents were tested using two-fold agar dilution and broth microdilution. The resistance genes were characterized through whole genome sequence analysis. The bacteria typing was investigated through multilocus sequence typing (MLST), core genome MLST(cgMLST).
A total of 251 VRE isolates including 247 Enterococcus faecium (VREfm) and 4 Enterococcus faecalis (VREfs) were collected in this study. More than 75% isolates were collected from urine. More than 89% isolates were resistant to teicoplanin. Besides glycopeptides, all the VRE isolates were resistant to penicillin, ampicillin and fluoroquinolones (VREfm) or erythromycin and fluoroquinolones (VREfs) and can be defined as multi-drug resistant. Among 247 VREfm, 72.9% (180/247) carried vanA gene, 0.8% (2/247) carried vanM gene, and 26.3% (65/247) carried both vanA and vanM genes. A total of 22 sequence types (STs) were identified, with ST80 (24.7%, 61/247) being the most predominant. cgMLST analysis revealed that ST80-CT8524 was the most common cluster among the VREfm isolates. All the 4 VREfs isolates harbored vanA gene and were assigned to 2 STs.
VREfm isolates belonging to ST80 in Beijing was most common. VanA was still the predominant van gene and increased coexistence of vanA and vanM was noteworthy.
PMID:
42328171
Bibliographic data and abstract were imported from PubMed on 22 Jun 2026.
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