Reference Interval Establishment for Four Coagulation Parameters Using Indirect Methods in a High-Altitude Chinese Population: A Retrospective Real-World Analysis.

Authors

Banjiu Zhaxi, Danni Mu, Shengfang Ye, Chaochao Ma, Zhen Da, Yichen Ma, Yumeng Gao, Shensong Li, Yixicuomu, Zhaxiyangzong, Jinrong Pang, Mingjun Zhan, Ling Qiu, Qu Dan, Xinqi Cheng, Zhijuan Liu

Published in

Journal of clinical laboratory analysis. Pages e70287. Jun 22, 2026. Epub Jun 22, 2026.

Abstract

This study utilized two indirect methods to establish reference intervals (RIs) for four coagulation parameters for the adult population in Tibet, a high-altitude region in Western China.
Coagulation Data, Including Activated Partial Thromboplastin Time (APTT), prothrombin Time (PT), thrombin Time (TT), and Fibrinogen (FIB) Obtained From the People's Hospital of Tibet Autonomous Region Between 2019 and 2023, Were Subjected to Box-Cox Transformation for Normalization and Tukey Method for Outlier Removal. the RIs Were Calculated Using Hoffmann and refineR Methods, Respectively.
A total of 5086, 5282, 5386, and 5377 test results for APTT, PT, TT, and FIB were included. The Hoffmann and refineR method yielded the following total RIs: APTT 30.54-46.32 and 30.14-44.30 s; PT 10.54-14.51 and 10.32-13.89 s; TT 14.92-19.46 and 14.88-18.93 s; FIB 2.05-4.68 and 2.02-4.40 g/L, respectively. Gender-partitioned RIs were calculated for all four parameters, while age-partitioned RIs were specifically calculated for PT and FIB based on bias ratio values. The lower limits of RIs estimated by the two methods remained consistent. The established RIs for APTT and FIB were significantly higher than those utilized in the plain area and those provided by the manufacturer, whereas the established RIs of TT were significantly lower.
The RIs for coagulation parameters in the population living on the Tibetan Plateau exhibited significant divergence from those utilized in the plain area. Specific RIs for high-altitude regions should be established to accurately evaluate the presence of coagulation disorders.

PMID:
42329361
Bibliographic data and abstract were imported from PubMed on 22 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.