Authors
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao
Published in
Advanced science (Weinheim, Baden-Wurttemberg, Germany). Pages e76235. Jun 22, 2026. Epub Jun 22, 2026.
Abstract
Tumor-associated carbohydrate antigens (TACAs), such as the Tn antigen, are promising targets for cancer vaccines but are limited by their low immunogenicity and a lack of T-cell responses. Traditional carrier-protein conjugates often encounter issues such as epitope suppression and heterogeneous formulations. Herein, we present the design, synthesis, and immunological evaluation of a chemically defined, four-component self-adjuvanting glycoconjugate. This molecule combines multiple innate immune activation strategies into a single, unimolecular framework, incorporating (1) a synthetic Tn as the B-cell epitope; (2) vizantin, a strong Mincle agonist, as an internal adjuvant; (3) rhamnose to attract endogenous antibodies for Fcγ receptor-mediated uptake; and (4) mannose to target dendritic cells through CD206. By ensuring precise co-delivery and synergistic activation of Mincle, Fcγ receptor, and CD206 pathways, this construct induces strong IgG switching, Th1‑type cytokine responses, and significant tumor suppression in mice. This research offers a versatile chemical approach for next‑generation TACA vaccines, illustrating how activating multiple innate pathways can overcome the longstanding limitations of carbohydrate-based immunotherapies.
PMID:
42330365
Bibliographic data and abstract were imported from PubMed on 23 Jun 2026.
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