Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota.

Authors

Jing Zhan, Yiran Liang, Donghui Liu, Xiaoran Ma, Peize Li, Chang Liu, Xueke Liu, Peng Wang, Zhiqiang Zhou

Published in

Microbiome. Volume 6. Issue 1. Pages 224. Dec 13, 2018. Epub Dec 13, 2018.

Abstract

Antibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host.
The oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expression and upregulating intestinal absorption-related proteins.
Antibiotics could increase the pesticide bioavailability and thereby may increase the pesticide exposure risk. The antibiotic-altered gut microbiota that could alter the hepatic metabolic enzyme gene expression and intestinal absorption-related proteome was a critical cause of the increased bioavailability. This study revealed an undiscovered potential health impact of antibiotics and reminded people to consider the co-exposed xenobiotics when taking antibiotics.

PMID:
30545405
Bibliographic data and abstract were imported from PubMed on 23 Jun 2026.

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