Nucleic sexual hormone receptor signaling pathways in breast cancer: function regulation, crosstalk, and therapeutic implications.

Authors

Kai Zeng, Anqi Wang, Hongmiao Sun, Chunyu Wang, Shengli Wang, Renlong Zou, Dongjun Yang, Yu Bai, Manlin Wang, Yingying Xu, Yue Zhao

Published in

NPJ precision oncology. Jun 22, 2026. Epub Jun 22, 2026.

Abstract

Sexual hormone receptors (SHRs) are essential for breast cancer (BCa) pathogenesis. BCa is a prevalent malignancy with high heterogeneity and high recurrence. Endocrine resistance remains a major clinical challenge. SHR-mediated transcription involves complex epigenetic, post-translational, and inter-receptor crosstalk, and dysregulation of these processes contributes to endocrine resistance. This review aims to summarize the current progress on the molecular mechanism underlying the function of nucleic SHRs in BCa, providing insights for the novel therapeutic strategies in BCa.

PMID:
42332013
Bibliographic data and abstract were imported from PubMed on 23 Jun 2026.

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