PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Authors

Hamsini Kala, Dana Abou Abbas, Linda H Malkas, Robert J Hickey

Published in

Advances in experimental medicine and biology. Volume 1514. Pages 157-188.

Abstract

With over 27,100 papers currently written about Proliferating Cell Nuclear Antigen (PCNA) and more than 11,700 papers describing a role for the protein and its relationship to cancer, this chapter will just touch upon some of the important role's PCNA has within cells and what types of proteins might interact with PCNA. This chapter is not meant to provide a thorough review of the multitude of protein complexes utilizing PCNA as a cofactor but rather highlight only some of those direct or indirect interactions between PCNA and its binding partners which together are involved in maintaining the genome, regulating cytoplasmic activities, and participating in immune surveillance. Additionally, this chapter will provide a high-level overview of how the caPCNA isoform is being used as a platform for a new class of anticancer therapeutic agent that selectively kills cancer cells, while leaving non-cancer cells unharmed.

PMID:
42334541
Bibliographic data and abstract were imported from PubMed on 23 Jun 2026.

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