Authors
Weiyu Hou, Weiming Hou
Published in
Psychiatric genetics. Apr 28, 2026. Epub Apr 28, 2026.
Abstract
This study aimed to investigate the causal associations and potential mechanistic pathways involving pulse rate, neuronal cell adhesion molecule (NrCAM), migraine, and other neurological disorders within the context of the glymphatic system.
Using bidirectional two-sample Mendelian randomization analysis, we constructed simple, parallel, and serial causal pathway diagrams based on significant genetic evidence, in combination with a disease network approach, to elucidate key relationships and plausible biological routes. Key findings indicate that pulse rate influences NrCAM expression, and NrCAM mediates the development of migraine. Neurological disorders such as stroke and Parkinson's disease were found to impact related molecular pathways. The study identifies NrCAM as a pivotal molecule in the glymphatic system, influenced by lifestyle factors and contributing to migraine pathogenesis. Moreover, pulse rate acts as an initiating factor driving molecular changes, with neurological disorders serving as mediators in the causal network.
The complex interplay between lifestyle, physiological factors, molecular mediators, and neurological disorders reveals an intricate network of causality in neurological disease. These findings underscore the importance of optimizing glymphatic function and highlight NrCAM as a potential therapeutic target. Understanding these interactions provides insights for developing targeted interventions and personalized treatment strategies for neurological disease prevention and management.
PMID:
42335026
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.
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