Authors
Edina A Wappler-Guzzetta, Daniel M Real, Shehla Aman, Chelsea Huang, Jeremy K Deisch, Laura J Denham
Published in
Physiology international. Jun 23, 2026. Epub Jun 23, 2026.
Abstract
The transmembrane receptor tyrosine kinase c-MET has a central role in granulosa cells in many physiological and pathological processes of granulosa cells, including cell survival and folliculogenesis. We therefore hypothesized that c-MET may be expressed in granulosa cell tumors (GCTs).
c-MET immunostaining was performed retrospectively on human GCT specimens, including adult (n = 19) and juvenile GCTs (n = 2). Data was collected on patient demographics, tumor stage, and size. Furthermore, staining intensity was analyzed by a staining intensity score, and the presence or absence of membranous staining was noted. Multivariate logistic regression was used for statistical analysis, with P < 0.05 being considered statistically significant. Juvenile GCTs were excluded from the statistical analysis.
Both cytoplasmic and membranous staining was seen in GCT tissues, with the majority (∼74%) of the adult and both juvenile cases showing positive membranous staining. As expected, vascular endothelial cells were also c-MET positive in the tumor tissue. Amongst the adult GCT patients, tumor mitotic activity was higher with older age (r = 0.531; P = 0.019). Also, smaller tumors had higher c-MET intensity scores (r = -0.579, P = 0.038).
Most GCTs were c-MET positive by immunostaining along with the vascular endothelial cells, highlighting the potential of c-MET inhibition as a therapeutic option in these tumors.
PMID:
42334874
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.
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