Yield of Fecal Immunochemical Test Screening for Colorectal Cancer in Adults Aged 45-49 vs 50-54 years.

Authors

Le Wang, Chen Zhu, Yu Qiu, Weimiao Wu, Tingting Pan, Weiwei Gong, Shi Wang, Wei Wu, Dong Hang, Ni Li, Partha Basu, Lingbin Du

Published in

The American journal of gastroenterology. Jun 24, 2026. Epub Jun 24, 2026.

Abstract

The rising incidence of early-onset colorectal cancer (CRC) has prompted debate over lowering screening initiation age. However, real-world evidence on fecal immunochemical test (FIT)-based screening effectiveness in 45-49 years remains limited. Our study aimed to evaluate screening yield of FIT-based CRC screening between 45-49 and 50-54 years.
Conducted within a provincial CRC screening program in China, this study employed two-sample FIT screening followed by colonoscopy for positive results. Screening outcomes, including FIT positivity, colonoscopy completion, positive predictive values (PPVs) and detection rates of adenoma and advanced colorectal neoplasia, were compared between participants aged 45-49 and 50-54 years. Robust Poisson regression was used to estimate adjusted risk ratios (aRRs), using 50-54-year-old group as reference.
Among 733,137 participants, 89,446 were aged 45-49 years and 643,691 aged 50-54 years. Participants aged 45-49 years had higher FIT positivity (10.61%) and colonoscopy completion (46.75%) than those aged 50-54 years. However, detection rates for advanced neoplasia (0.30% vs. 0.39%; aRR, 0.78; 95% CI, 0.68-0.88) and any adenoma (0.78% vs. 0.95%; aRR, 0.83; 95% CI, 0.77-0.90) were significantly lower in the younger group, with similar results observed for PPVs. Within the 45-49 year group, comparable detection rates to 50-54 year age group were observed among individuals with established risk factors, most notably among smokers (RR, 1.50; 95% CI, 1.22-1.84), frequent alcohol drinkers (RR, 1.33; 95% CI, 1.01-1.75), and males (RR, 1.20; 95% CI, 1.03-1.40).
Overall, adults aged 45-49 years showed higher screening participation but lower screening yield than those aged 50-54 years. These findings highlight the importance of prioritizing individuals with elevated risk profiles for CRC screening in younger populations.

PMID:
42335418
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

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