Authors
Yanfei Liu, Luxin Wang, Xincan Zhou, Zhiyue Li, Xiao Ruan, Han Su, Weihong Zhang, Fangyuan Liu
Published in
Lymphatic research and biology. Pages 15578585261461399. Jun 23, 2026. Epub Jun 23, 2026.
Abstract
Cancer-related fatigue (CRF) is the most common symptom of cancer patients. This study aimed to investigate the prevalence of CRF among patients with breast cancer-related lymphedema (BCRL) and to indentify the factors associated with its occurrence.
In this cross-sectional study, women with BCRL (N = 260) were recruited from the three general hospitals. Lymphedema status was determined using the Norman telephone questionnaire as the patient-reported occurrence of hand/lower arm/upper arm swelling. CRF status was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue questionnaire. Multiple binary logistic regression analysis was used to identify factors associated with CRF.
The median time from BC diagnosis was 29 months (interquartile range, 15.0-62.0 months). The prevalence of CRF among BCRL patients was 88.46%. The median sedentary time was 245 min/day (IQR: 150-330min/day), and 34.23% of the patients did not meet the moderate-intensity physical activity level. Abnormal postoperative wound healing status, radiotherapy, hormonal therapy, lymphedema severity and failure to meet moderate-intensity physical activity level were associated with an increased risk of CRF.
CRF is highly prevalent among patients with BCRL. Targeted interventions aimed at promoting moderate-intensity physical activity and improving long-term symptom management may help alleviate fatigue.
PMID:
42334920
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.
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