Association between interleukin-10 (IL-10) genetic polymorphisms and non-hodgkin lymphoma: a systematic review and meta-analysis.

Authors

Rifah Nanjiba Jahan, Md Hijbullah, Lubaba Nawal, Kazi Farhin Lamisa, Mahima Akhter, Alam Nashrah, Fariha Ahammed Simran, Muhammed Mahfuzur Rahman, Mohd Nazmul Hasan Apu, Md Shaki Mostaid

Published in

Leukemia & lymphoma. Pages 1-21. Jun 23, 2026. Epub Jun 23, 2026.

Abstract

Non-Hodgkin lymphoma (NHL) has been associated with IL-10 single-nucleotide polymorphisms (SNPs), although findings remain inconsistent. This meta-analysis aims to investigate the association between key IL-10 SNPs (rs1800871, rs1800872, rs1800890, and rs1800896) with NHL. A systematic search of multiple databases was conducted to get relevant articles. The study included 53,864 cases and 60,448 controls from 41 studies. Pooled ORs with 95% CIs were calculated for each SNP, along with a heterogeneity test and publication bias analysis. The SNP rs1800890 showed modest but significant associations with NHL risk in codominant 1 (OR = 1.12, p < 0.001), codominant 2 (OR = 1.06, p = 0.006), and recessive models (OR = 1.08, p = 0.002); rs1800896 showed weak significant associations with NHL risk in dominant (OR = 1.08, p = 0.001) and codominant 2 models (OR = 1.07, p = 0.006). Subgroup analysis based on ethnicity revealed a nominally significant protective association in Caucasians for rs1800871 in the allelic model (OR = 0.87, p = 0.038).

PMID:
42335190
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

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