Single-cell catalogue of immune cells from Japanese individuals.

Authors

Yukie Kashima, Kenichi Makishima, Genta Fujii, Masahide Seki, Yuuta Kuze, Patrick Reteng, Mamiko Sakata-Yanagimoto, Yutaka Suzuki

Published in

Communications biology. Jun 23, 2026. Epub Jun 23, 2026.

Abstract

Gene expression in immune cells varies greatly among healthy individuals and may be influenced by the genetic background, age and other factors. However, the molecular mechanisms underlying immune diversity at the single-cell level are not well understood. Here, we generate a single-cell multi-omics dataset of peripheral blood from 105 Japanese individuals. We focus on age-related changes in cellular populations and gene expression levels. In our dataset, age-associated population changes are most pronounced in naïve T cells, memory B cells, and CD56^bright NK cells, which are associated with the initial immune responses of the respective cell lineages. Conversely, monocytes display prominent epigenomic changes that often precede those in the transcriptome, particularly among immune response genes. This dataset, which represents an underrepresented Japanese population in single-cell research, provides an invaluable resource for future studies.

PMID:
42337162
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.