Spatial control of NLRP3 inflammasome assembly by membrane lipid composition.

Authors

Paras K Anand, Najd M Aljadeed

Published in

Communications biology. Volume 9. Issue 1. Jun 23, 2026. Epub Jun 23, 2026.

Abstract

The NLRP3 inflammasome has been shown to assemble on multiple organelles, including the mitochondria, endoplasmic reticulum, trans-Golgi network, and endosomes. Yet, the precise site of assembly remains unresolved. Emerging evidence suggests that membrane lipid composition may play a critical role with phosphoinositides, cholesterol, and cardiolipin, alongside membrane biophysical properties and cellular metabolic state, collectively shaping membranes where inflammasome assembles. Here, we review how lipid-dependent mechanisms regulate NLRP3 assembly across membranes and consider whether a defined membrane lipid signature governs inflammasome assembly. This understanding may have broader implications for therapeutic targeting in inflammatory and metabolic diseases.

PMID:
42337306
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

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