Enhanced upconversion nanoparticles as turn-on fluorescent nanosensors for determination of Porcine epidemic diarrhea virus.

Authors

Yawen Rong, Yue Liu, Fei Kong, Hongxu Zhu, Jingyi Fang, Yuan Gao, Qian Zhao, Md Mehedi Hassan, Jun Huang

Published in

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. Volume 363. Issue Pt 1. Pages 128270. Jun 16, 2026. Epub Jun 16, 2026.

Abstract

Porcine epidemic diarrhea virus (PEDV) can cause diarrhea, vomiting, dehydration and high mortality in pigs, resulting in significant economic losses for the swine industry. The current research intelligently converges core-shell upconversion nanoparticles (CSUCNPs) and molybdenum disulfide nanosheets modified magnetic nanoparticles (MNPs@MoS₂) to achieve the diagnosis of PEDV. The scheme employs the inner filter effect via between CSUCNPs and MNPs@MoS₂. With the existence of PEDV, the aptamers bind to PEDV preferentially and interrupt the IFE, thus leading the recoveries of upconversion fluorescence. Therefore, PEDV can be quantified by the linear curve between fluorescence intensity and logarithm concentration of PEDV at the range of 0.01-10⁴ μg/L. This proposed nanosensor exhibits a satisfied detection of limit as 0.021 μg/L. Importantly, a real sample test was performed and compared with standard method, the results suggested the nanosenor demonstrates excellent accuracy and reproducibility, and has promising application prospects.

PMID:
42335697
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

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