P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure.

Authors

Qianqian Niu, Huidan Wang, Mengyao Zhao, Hongdou Zhang, Rui Hao, Peiyao Liu, Lijuan Guo, Bulei Chen, Yuting Xi, Peng Li, Yaling Yin

Published in

Molecular and cellular biochemistry. Jun 24, 2026. Epub Jun 24, 2026.

Abstract

Doxorubicin (DOX)-induced cardiotoxicity is closely associated with oxidative stress, DNA damage, and senescence-related cardiac injury. This study evaluated the protective effects of Floralozone against DOX-induced cardiac injury and explored the associated molecular changes. Floralozone alleviated DOX-induced cardiac dysfunction, myocardial structural damage, oxidative stress, DNA damage responses, and senescence-related changes in vivo and in vitro. These protective effects were accompanied by modulation of the P2Y12-AMPKα2-ASK1-MEK3-related stress signaling axis. These findings suggest that Floralozone may protect against DOX-induced cardiac injury by suppressing oxidative stress, attenuating DNA damage responses, and reducing senescence-related signaling.

PMID:
42340549
Bibliographic data and abstract were imported from PubMed on 24 Jun 2026.

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