Beyond Static Subtypes in Large B-cell Lymphoma: Context, Plasticity, and Therapeutic Logic.

Authors

Laura K Hilton, Christopher R Flowers, Jean L Koff

Published in

Blood cancer discovery. Pages OF1-OF5. Jun 24, 2026. Epub Jun 24, 2026.

Abstract

Although genomic classifiers have provided unprecedented insights into the biology of large B-cell lymphoma (LBCL), their ability to consistently predict outcomes across diverse patient populations and therapeutic contexts remains limited. Increasing evidence suggests that integrated models incorporating tumor genetics, transcriptional state, microenvironmental programs, and ancestry-informed biology will be required to realize the full promise of precision medicine in LBCL.

PMID:
42341193
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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