Inflammatory monocytes constrain YAP-induced cell proliferation.

Authors

Serrena Singh, Nareh Tahmasian, Jia-Jun Liu, Wenjia Wang, Lucas Haas, Yingdong Zhu, Magdalena M Griswold, Nina N Brodsky, Silvia Liu, Brian T Kalish, Dean Yimlamai

Published in

Science advances. Volume 12. Issue 26. Pages eaee8580. Jun 26, 2026. Epub Jun 24, 2026.

Abstract

YAP and its paralog, TAZ, are transcriptional coactivators of the Hippo pathway that regulate cell growth. Their structural distinctiveness suggests important independent functional differences. To investigate this further, we generated YAP- and TAZ-predominant clones in the liver and followed their long-term behavior. YAP clones rapidly dedifferentiate cells into a stem cell-like state with inflammatory immune cell recruitment followed by their clearance. In contrast, TAZ clones promote an anti-inflammatory immune environment, resulting in their long-term maintenance, massive organ growth, and increased mortality. YAP clones recruit inflammatory blood-derived monocytes, which, if inhibited, permits YAP clonal growth. Consistent with these results, patients with YAP^High colorectal cancer (CRC) had a 67% 5-year survival rate, whereas patients with TAZ^High CRC did not survive to 5 years. Similar trends were seen in patients with hepatocellular carcinoma. These findings underscore the importance of understanding the intrinsic differences in YAP and TAZ biology as independent drivers of disease.

PMID:
42341114
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.