Authors
Giorgia Nasi, Leonie C Schöftner, Lara Ronacher, Amalia Sophianidis, Julia Feiser, Teodora Aleksandrova, Oliver Nussbaumer, Andrew Hutton, Roland Zauner, Johanna Moser-Waxenecker, Suraj R Varkhande, Anshu Sharma, Monika Ettinger, Teresa Burner, Martin Laimer, Christina Guttmann-Gruber, Iris K Gratz
Published in
Science advances. Volume 12. Issue 26. Pages eaec7215. Jun 26, 2026. Epub Jun 24, 2026.
Abstract
Gamma delta (γδ) T cells are critical for tissue immune surveillance and their presence in tumors correlates with a favorable prognosis, highlighting their therapeutic potential. Although γδ T cells are abundant in the skin, their therapeutic value in skin cancer has remained largely unexplored due to challenges in isolating sufficient numbers of γδ T cells from human tissues and a lack of suitable preclinical models for skin cancer. Here, we are using innovative methods to expand human cutaneous γδ T cells ex vivo, enabling us to investigate their therapeutic potential in a human cutaneous squamous cell carcinoma (cSCC) mouse model. In this model, γδ T cells were specifically recruited to and maintained in the cSCC xenograft. These tumor-infiltrating cells exhibited an activated, cytotoxic phenotype and demonstrated effective antitumor activity in vivo. Collectively, our findings provide preclinical evidence supporting human skin-resident γδ T cells as a promising immunotherapeutic approach for treating skin cancers such as cSCC.
PMID:
42341104
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.
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