Thianthrenium Salts Enable Regio- and Stereoselective C(sp²)-H Arylation of Enamides with Simple Arenes.

Authors

Ruo-Nan Cao, Meng-Wei Sheng, Meng-Ting Chu, Meng-Yang Wang, Ming-Zhu Lu

Published in

The Journal of organic chemistry. Jun 24, 2026. Epub Jun 24, 2026.

Abstract

We report a palladium(II)-catalyzed regio- and stereoselective β-C(sp²)-H arylation of enamides with simple arenes under base- and ligand-free conditions via thianthrenium salts, affording a broad array of geometrically defined β-arylated enamides with an exquisite Z configuration. This transformation is characterized by operational simplicity, readily available and bench-stable aryl surrogates, broad substrate scope, and extraordinary compatibility with diverse functionalities. The utility of this approach has been demonstrated by the late-stage diversification of biologically active molecules.

PMID:
42341196
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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