Authors
Ayfer Çalış, Atakan Tevlek, Kadriye Özcan, Doğan Acar, Mehmet Yılmaz, Salih Durdu
Published in
Scientific reports. Jun 24, 2026. Epub Jun 24, 2026.
Abstract
In this study, chitosan, polydopamine and polydopamine/chitosan coatings were coated on AZ61L magnesium by dip coating process. Thus, the surface characteristics, wettability and in vitro biological properties including bacteria and cell behavior of chitosan (Mg-C), polydopamine (Mg-D), polydopamine/chitosan (Mg-C-D) layers fabricated on AZ61L alloy were investigated in this work. The surfaces were characterized by X-ray diffractometer, scanning electron microscope, energy dispersive spectrometer, contact angle goniometer and surface profilometer. The Mg-D and Mg-C coatings indicated hydrophilic behavior while the Mg-C-D coatings exhibited hydrophobic character. Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, while cell death was confirmed by acridine orange/propidium iodide fluorescence staining. The results demonstrated that all coated surfaces significantly improved cellular responses compared to bare Mg, with the Mg-C-D coating exhibiting the highest cell viability and enhanced cytocompatibility. Antibacterial activity was determined using the agar diffusion method against Staphylococcus aureus (ATCC6538). Furthermore, antibacterial tests revealed that Mg-C-D surfaces showed superior inhibition against bacterial growth compared to single-layer coatings, indicating a synergistic effect between chitosan and polydopamine. These findings demonstrate that the combined coating strategy provides an effective approach to enhance both biocompatibility and antibacterial performance of Mg-based alloys for biomedical applications.
PMID:
42342909
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.
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