Authors
Leen J M Seys, Laurens Zwanenburg, Jimmy Borloo, Bregt Decorte, Stijn Casaert, Nathalie Dewilde, Iris Peelaers, Thomas Geurden, Edwin Claerebout, Peter Geldhof
Published in
Scientific reports. Jun 24, 2026. Epub Jun 24, 2026.
Abstract
Gastrointestinal nematode infections are a common burden in farm animals. As the prevalence of anthelmintic resistance is rising, vaccination is considered a promising alternative for preventive anthelmintic treatments. In search of a vaccine candidate against the bovine small-intestinal helminth Cooperia oncophora, a mid-molecular weight protein fraction (MMW) was isolated from C. oncophora excretory-secretory (ES) material and was protective in a vaccination-infection model. Consequently, the most abundant MMW protein, i.e. a single domain activation-associated secreted protein (Co-sdASP), was purified and evaluated in two vaccine trials, first in a three-dose (initial dose + two repeats) and subsequently in a two-dose (initial dose + one repeat) regimen. The three-dose regimen with native Co-sdASP resulted in 86% reduction in parasite egg output and 63% reduction in worm burden following challenge infection, while the two-dose regimen reduced egg output by 64% but did not significantly affect worm burden. Analyses of immune responses in both vaccination regimens showed that CD4 + T cells and B cells of vaccinated animals exhibited significantly higher proliferation in response to ex vivo restimulation with vaccine antigen, compared to cells from the control groups. In conclusion, Co-sdASP is a promising antigen for vaccinating cattle against C. oncophora infections.
PMID:
42342817
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 6
- Comments 0