BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine.

Authors

Sören Reinke, Marta Ulaszewska, Qi Su, Lee Sims, Romain Guyon, Adam Truby, Gundra Raissar, Jelena S Bezbradica, Joannah R Fergusson, Anita Milicic

Published in

NPJ vaccines. Jun 24, 2026. Epub Jun 24, 2026.

Abstract

BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8⁺ T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.

PMID:
42342712
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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