Authors
Zoubida Tazi Mezalek, Wafaa Mounfaloti, Fatima Zahra Iraqi, Wafaa Ammouri, Hicham Harmouche, Mouna Maamar, Rachid Razine
Published in
TH open : companion journal to thrombosis and haemostasis. Volume 10. Pages a28900814. Epub Jun 19, 2026.
Abstract
Patients with venous thromboembolism (VTE) frequently require vitamin K antagonists (VKAs) to treat and prevent recurrent events.
We performed a study to assess the quality of anticoagulation in patients with VTE treated with VKAs using time in therapeutic range (TTR), to identify associated factors with predictors of poor control and outcomes in VTE patients.
We performed an observational, retrospective study that included VTE patients treated with VKA. The primary outcome was the TTR calculated according to the Rosendaal algorithm.
A total of 171 VKA-treated patients were evaluated (53.2% men). The average age of our patients at diagnosis was 49.8 + 16.6 years [17-92]. VTE's most common location was the lower limbs, with 91.8% cases, proximal in 83.6%. Patients were followed for a mean period of 178 days. The mean TTR was 41.2% (standard deviation: 32.9%), and 74.3% of the patients had a mean TTR < 65%. The rates of major bleeds and thromboembolic events were 0.5 and 2.2%, respectively. After multivariate statistical analysis, age older than 65 and surgery provoked VTE were associated with better TTR.
These results are informative and may help identify patients who require closer monitoring or innovative strategies to optimize oral anticoagulant therapy outcomes.
PMID:
42343974
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 1
- Comments 0