[The research and development trends in the biosynthesis of 7-aminocephalosporanic acid based on patent analysis].

Authors

Wencheng Su, Chongming Wu, Yi Xu, Xian Zhang, Zhoutong Sun

Published in

Sheng wu gong cheng xue bao = Chinese journal of biotechnology. Volume 42. Issue 6. Pages 2482-2501. Jun 25, 2026.

Abstract

7-aminocephalosporanic acid (7-ACA) is the core nucleus of cephalosporin antibiotics, and its green and efficient synthesis has become a research hotspot in the field of biopharmaceutical manufacturing. To reveal the global innovation trends and competitive landscape of 7-ACA biosynthesis technologies, this study systematically analyzes related patents from 1956 to 2024 based on the Incopat patent database, employing patentometrics and visualization methods. The results showed that global research and development in 7-ACA biosynthesis had undergone three phases: technological exploration from 1956 to 1987, rapid development from 1988 to 2010, and the period after 2011 when China emerged as the primary contributor. In terms of technical directions, patents related to cephalosporin C acylase were the most (73), among which enzyme engineering was the most active subfield. Strain engineering focused on multi-platform construction involving Acremonium chrysogenum and Saccharomyces cerevisiae. Patent applicant analysis revealed that Royal DSM held a strong historical position, while institutions such as Tianjin Institute of Industrial Biotechnology (Chinese Academy of Sciences), Amicogen Biopharm and Yili Chuanning Biotechnology Company Limited stood out in terms of granted and pending patents, demonstrating robust sustained innovation capacity. Regarding patent strategy, it is recommended that China should strengthen PCT international filings, build robust patent portfolios, and foster industry, university and research collaboration to enhance its global competitiveness in high-end pharmaceutical intermediates. This study offers strategic insights into technical route identification, patent portfolio construction, industrial competition, and collaborative innovation mechanisms. It provides critical patent intelligence for the development of China's 7-ACA industry and serves as a valuable reference for research on other antibiotic intermediates.

PMID:
42343793
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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