Immuno-instructive biomaterials for coronary artery disease and myocardial infarction repair.

Authors

Xuanfu Chi, Chaowei Wu, Feifei Ni, Tai Zeng, Songsong Wu, Yunrui Zhang

Published in

Journal of materials science. Materials in medicine. Jun 25, 2026. Epub Jun 25, 2026.

Abstract

Coronary artery disease (CAD) and myocardial infarction (MI) feature a highly dynamic inflammatory milieu. While reperfusion remains essential, it does not sufficiently correct immune dysregulation or prevent adverse remodeling. Biomaterials offer a complementary strategy by enabling spatiotemporally controlled immunomodulation and tissue repair. By providing localized delivery of bioactive cues, mechanical support to stabilize the infarct wall, and immuno-instructive interfaces that steer macrophages toward reparative phenotypes, biomaterial platforms can reshape the post-infarction microenvironment. This review summarizes recent biomaterial-mediated strategies for the treatment of coronary heart disease. By integrating advances in immunomodulatory design, controlled drug delivery, and cardiac tissue engineering, it highlights how biomaterials can reshape the post-ischemic microenvironment to improve repair and limit adverse remodeling. These insights not only clarify current opportunities and translational barriers, but also provide guidance for developing next-generation, phase-adaptive and clinically scalable biomaterial platforms.

PMID:
42348021
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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