Rapid and Atom-Economical De Novo Access to Polysubstituted Quinolines via Sequential C-C Bond Cleavage and Reassembly.

Authors

Yahui Zhang, Chao Pi, Yangjie Wu, Xiuling Cui

Published in

Organic letters. Jun 25, 2026. Epub Jun 25, 2026.

Abstract

Herein, we report a Cu(II), Rh(III) relay-catalyzed multicomponent reaction of easily available arylformylacetonitriles and alkynes, enabling the efficient de novo synthesis of polysubstituted quinolines via two steps in a "one-pot" manner. Various polysubstituted quinolines could be provided in up to 88% yields for 23 examples. The title products exhibit favorable fluorescence emission. Mechanistic studies suggest that unique domino two-C-C bond cleavage and the formation of multiple new bonds (five C-C bonds and one C-N bond) are involved in this process. This protocol features mild reaction conditions and is extremely simple and scalable. The luminescence of the products enhances their promising applications in functional materials.

PMID:
42348310
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

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