Parametrization of microbial survival models under UVC exposure.

Authors

Aikaterini A Tsantari, Konstantinos K Delibasis, Harilaos G Sandalidis, Nestor D Chatzidiamantis

Published in

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. Jun 25, 2026. Epub Jun 25, 2026.

Abstract

This work presents a unified framework for the parametrization and comparison of microbial survival models under UVC exposure. Four dose-response models-the single-target, multi-target, linear-quadratic, and two-stage decay models-are analyzed with respect to their mathematical structure, parameter identifiability, and biological interpretability, while ensuring physically meaningful parameter estimates. To address the limited size and lack of replication in published datasets, parameter uncertainty is quantified using a parametric bootstrap approach under multiplicative dose uncertainty. Model comparison combines goodness-of-fit in logarithmic survival space, the Akaike Information Criterion corrected for small samples, and identifiability considerations. Application to data for 32 microorganisms shows that no single model is universally optimal, highlighting that reliable model selection requires combining statistical performance with physical and biological consistency, and providing a robust basis for UVC survival analysis and disinfection modeling.

PMID:
42348094
Bibliographic data and abstract were imported from PubMed on 25 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.