Authors
Mabel R Challapa-Mamani, Eduardo Tomás-Alvarado, Angela Espinoza-Baigorria, Darwin A León-Figueroa, Ranjit Sah, Alfonso J Rodriguez-Morales, Joshuan J Barboza
Published in
Tropical medicine and infectious disease. Volume 8. Issue 10. Sep 26, 2023. Epub Sep 26, 2023.
Abstract
Leishmaniasis, a disease caused by Leishmania parasites and transmitted via sandflies, presents in two main forms: cutaneous and visceral, the latter being more severe. With 0.7 to 1 million new cases each year, primarily in Brazil, diagnosing remains challenging due to diverse disease manifestations. Traditionally, the identification of Leishmania species is inferred from clinical and epidemiological data. Advances in disease management depend on technological progress and the improvement of parasite identification programs. Current treatments, despite the high incidence, show limited efficacy due to factors like cost, toxicity, and lengthy regimens causing poor adherence and resistance development. Diagnostic techniques have improved but a significant gap remains between scientific progress and application in endemic areas. Complete genomic sequence knowledge of Leishmania allows for the identification of therapeutic targets. With the aid of computational tools, testing, searching, and detecting affinity in molecular docking are optimized, and strategies that assess advantages among different options are developed. The review focuses on the use of molecular docking and molecular dynamics (MD) simulation for drug development. It also discusses the limitations and advancements of current treatments, emphasizing the importance of new techniques in improving disease management.
PMID:
37888585
Bibliographic data and abstract were imported from PubMed on 26 Jun 2026.
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