The Role of S100A6 in Human Diseases: Molecular Mechanisms and Therapeutic Potential.

Authors

Fengguang Yang, Jinglin Ma, Daxue Zhu, Zhaoheng Wang, Yanhu Li, Xuegang He, Guangzhi Zhang, Xuewen Kang

Published in

Biomolecules. Volume 13. Issue 7. Jul 17, 2023. Epub Jul 17, 2023.

Abstract

S100A6, also known as calcyclin, is a low-molecular-weight Ca²⁺-binding protein from the S100 family that contains two EF-hands. S100A6 is expressed in a variety of mammalian cells and tissues. It is also expressed in lung, colorectal, pancreatic, and liver cancers, as well as other cancers such as melanoma. S100A6 has many molecular functions related to cell proliferation, the cell cycle, cell differentiation, and the cytoskeleton. It is not only involved in tumor invasion, proliferation, and migration, but also the pathogenesis of other non-neoplastic diseases. In this review, we focus on the molecular mechanisms and potential therapeutic targets of S100A6 in tumors, nervous system diseases, leukemia, endometriosis, cardiovascular disease, osteoarthritis, and other related diseases.

PMID:
37509175
Bibliographic data and abstract were imported from PubMed on 26 Jun 2026.

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