Authors
Wangping Luo, Xiaoyan Yang, Yining Wang, Jianxia Xu, Yijie Lou, Jiayi Chen, Jue Hou, Xiaojie Wang, Yuanfei Lu, Jin Mao, Guping Tang, Hongzhen Bai, Risheng Yu
Published in
Journal of nanobiotechnology. Jun 26, 2026. Epub Jun 26, 2026.
Abstract
Colorectal cancer liver metastasis (CRLM) poses a major challenge in cancer theranostics, in which hepatic stellate cell (HSC) activation participates in fibrosis progression and colorectal cancer (CRC) cell recruitment, catalyzing the formation of fibrosis-concomitant premetastatic niche (PMN). Targeting the crosstalk between activated HSCs (aHSCs) and CRC cells, we develop a bioengineered, mesoporous superparamagnetic iron oxide nanoparticle (mSPIONP)-based theranostic nano-system (mSPIONP-Cur@eCM). Camouflaged with CXC chemokine receptor type 4 (CXCR4)-overexpressing CRC cytomembranes, this nano-system exhibits a dual PMN-targeting function, exerting a homologous recognition to CRC cells and anchors to aHSCs with a high secretion of stromal cell-derived factor-1 (SDF-1). Its mSPIONP-Cur core affords not only T2-weighted magnetic resonance imaging (MRI) but also curcumin (Cur) delivery, initiating liver fibrosis detection and metastasis foci delineation, simultaneously blocking the HSC-CRC cell crosstalk by amplifying Cur's therapeutic effect. Verified in fibrosis and CRLM models, mSPIONP-Cur@eCM exhibits great potential for suppressing the fibrosis-concomitant PMN and intervening the CRLM progression.
PMID:
42351108
Bibliographic data and abstract were imported from PubMed on 26 Jun 2026.
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