Interorgan Communications in Skeletal Pathophysiology: From Molecular Pathways to Multidisciplinary Therapies.

Authors

Donghao Gan, Lei Qin, Guozhi Xiao

Published in

Research (Washington, D.C.). Volume 9. Pages 1319. Epub Jun 24, 2026.

Abstract

Communications between organs contribute to propel physiological functions, as well as pathological processes. Growing evidence indicates that bone is continuously regulated by multiple layers of endocrine, immune, metabolic, and neural networks. The common bone diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration, are reported with tight associations to other nonbone organs. These organ-bone axes emphasize the interorgan communications that maintain the bone homeostasis and maintain individual health. In this review, we systematically summarize recent advances in the organ-bone communications, highlighting mechanistic innovations, such as the gut-bone-immune axis, neuro-immune-bone integration, hypothalamic-pituitary-adrenal axis, adipo-neuro-bone axis, and their connections with bone pathophysiology. Furthermore, we highlight circulating biomarkers and imaging advances reflecting organ-bone crosstalk. Finally, we discuss the clinical relevance, current research gaps, and unsolved questions of organ-bone communications in the diagnostic stratification, treatment selection, and multidisciplinary management of bone diseases.

PMID:
42359046
Bibliographic data and abstract were imported from PubMed on 26 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.