Sézary Syndrome: Survival Trends, Racial Disparities, and Limited Prognostic Value of Routine Registry Variables.

Authors

Tiantian Zhang, Weili Xue, Zhe Wang, Simo Du

Published in

EJHaem. Volume 7. Issue 4. Pages e70332. Epub Jun 24, 2026.

Abstract

Sézary syndrome (SS) is a rare leukemic cutaneous T-cell lymphoma with limited contemporary population-level outcome data.
Using SEER-22, we identified 403 adults with first primary SS diagnosed from 2000-2021 and evaluated survival, disparities, and prognostic modeling.
Median overall survival (OS) was 48 months; 5-year OS was 42.7%. Survival improved from 39.5 months in 2000-2010 to 56.0 months in 2011-2021. Black patients were diagnosed younger and had worse adjusted mortality than White patients. Machine-learning and conventional models showed limited discrimination.
SS remains highly lethal, with persistent racial disparities and limited prognostic value of routine registry variables.
The authors have confirmed clinical trial registration is not needed for this submission.

PMID:
42359026
Bibliographic data and abstract were imported from PubMed on 26 Jun 2026.

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