Unique occurrence of trichilemmal carcinoma in the scrotal skin of a giant panda: a pathological analysis.

Authors

Chengyao Li, Zongliang Xiong, Shanshan Ling, Yan Zhu, Linhua Deng, Mengfang Yang, Chengdong Wang, Qian Wang, Danyu Chen, Mao Huang, Kao Wang, Desheng Li, Zhengli Chen, Caiwu Li

Published in

BMC veterinary research. Jun 26, 2026. Epub Jun 26, 2026.

Abstract

Trichilemmal carcinoma (TC) is a rare cutaneous appendage malignancy with scarce human cases and very few animal cases have been documented in the available literature, especially in giant pandas.
A 23-year-old male captive giant panda had 4-week scrotal hyperplasia and ulceration, with a 4.5 cm×4 cm irregular lesion and neutrophils were elevated. Pathology revealed dermal lobular/cord-like invasive atypical clear cells, squamous nests and outer root sheath cysts. PAS staining was positive. Immunohistochemistry showed Her-2 (+), CK5/6 (++), p63 (++), Ki-67 (+), CD34 (+), and p53 (+), excluding squamous cell carcinoma and trichofolliculoma. Local resection (0.8 cm margin) was done under general anesthesia. Postoperative anti-infection led to 2-week wound healing; 3-month follow-up showed no recurrence with normal behavior.
This first reported giant panda TC with human-like immunophenotype provides evidence for managing rare animal cutaneous appendage tumors.

PMID:
42363183
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

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