Degree of islet function preservation and continuous glucose monitoring in individuals undergoing total pancreatectomy with islet autotransplantation.

Authors

Maarten C Tol, Willemijn E M E de Vos, Ian P J Alwayn, J Sven D Mieog, Jeanin E van Hooft, Akin Inderson, Marieke Niesters, Marieke D Hellinga, Michiel F Nijhoff, Arian R van Erkel, Marten A Engelse, Volkert A L Huurman, Eelco J P de Koning

Published in

Diabetologia. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

In individuals undergoing total pancreatectomy, an additional islet autotransplantation (total pancreatectomy with islet autotransplantation [TPIAT]) can be performed. We investigated the degree to which islet secretory function is preserved after TPIAT and assessed the relation to glycaemic control using continuous glucose monitoring.
Eligibility for TPIAT was assessed by a multidisciplinary team. The cohort consisted of all individuals undergoing TPIAT from 2014 to 2024. To assess islet secretory function, participants were subjected to a 2 h liquid meal stimulation test prior to TPIAT, at 3 months and annually post TPIAT. Glycaemic control was assessed using continuous glucose monitoring and HbA_1c.
Twenty-six individuals were included, of whom 88.5% had chronic pancreatitis. At baseline, 57.7% had prediabetes (HbA_1c 39-47 mmol/mol [5.7-6.4%] or a fasting glucose 5.6-6.9 mmol/l) or diabetes, and 46.2% had undergone previous pancreatic surgery. Islet secretory function determined by C-peptide area under the curve (AUC_C-peptide) was 45% of baseline at 3 months post TPIAT. Preservation of islet secretory function was independent of preoperative glycaemic status and previous surgery. At 3 months, time in range was 75.2 ± 26.1%, and time in range was positively correlated with AUC_C-peptide (p<0.0001). After 3 months islet function did not significantly change, which was reflected in a stable BETA-2 score.
Nearly half of islet secretory function is retained after TPIAT. These results can facilitate shared decisions on the potential benefits of islet autotransplantation after total pancreatectomy, even in individuals with (pre)diabetes and previous pancreatic surgery.

PMID:
42362969
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.