Unmasking atypical dengue: A case of multi-organ failure and acute coronary syndrome.

Authors

Saad Ahmed Naved, Ghazia Hussain, Shamona Arshad, Naveed Latif, Muhammad Ashraf

Published in

JPMA. The Journal of the Pakistan Medical Association. Volume 76. Issue 6. Pages 957-960.

Abstract

This case report discusses a rare and challenging presentation of dengue haemorrhagic fever (DHF) in a 62- year-old male, complicated by acute coronary syndrome (ACS) and multi-organ failure (MOF). The patient was initially afebrile, presented with respiratory symptoms, and was diagnosed with non-ST elevation myocardial infarction (NSTEMI) and cardiogenic shock. Dengue serology confirmed a secondary dengue infection with profound thrombocytopenia, respiratory failure, and cardiogenic shock. Coronary angiography revealed triple-vessel disease, prompting consideration of coronary artery bypass grafting (CABG). However, owing to severe dengue-related complications, a multidisciplinary team deferred surgery in favour of medical management, leading to gradual haemodynamic recovery. This case underscores the importance of recognising atypical dengue presentations, especially in endemic regions, and highlights the complex interplay between dengue and pre-existing coronary artery disease in acute coronary syndrome (ACS). Prompt diagnosis, multidisciplinary collaboration, and individualised management are crucial for improving the outcomes in severe dengue cases with cardiac involvement.

PMID:
42363343
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

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