Triple-Pulse ²³Na MRI Sequence (TriNa) for Simultaneous Acquisition of Spin-Density-Weighted and Fluid-Attenuated Images.

Authors

Chengchuan Wu, Leigh A Johnston, Yasmin Blunck

Published in

Magnetic resonance in medicine. Jun 26, 2026. Epub Jun 26, 2026.

Abstract

This study proposes a Triple-pulse ${}^{23}$ Na (TriNa) MRI sequence for simultaneous acquisition of spin density-weighted (SD) and fluid-suppressed (FS) ${}^{23}$ Na images.
TriNa employs three rectangular pulses and two ultrashort-TE readouts to simultaneously obtain spin density-weighted (TriNa-SD) and fluid-suppressed (TriNa-FS) ${}^{23}$ Na images in one acquisition. Additionally, a correction model incorporating relaxation dynamics was developed to reduce residual fluid artifacts. Simulations, phantom and in vivo experiments at 7T were performed to assess TriNa's SNR efficiency, quantitative accuracy, and robustness against off-resonance artifacts, in comparison to standalone SD and FS ${}^{23}$ Na sequences.
TriNa-SD exhibited high linear correlation with sodium concentration in the phantom. Phantom and in vivo experiments demonstrated that TriNa achieved high SNR efficiency in acquiring SD and FS images. The proposed off-resonance correction model effectively reduced fluid artifacts in TriNa-FS using TriNa-SD and an additional B ${}_0$ map.
The proposed sequence design enables simultaneous dual-contrast ${}^{23}$ Na MRI with high SNR efficiency and the proposed post-processing correction mitigates off-resonance artifacts in the TriNa-FS image.

PMID:
42363626
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

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