Antifungal turbinmicin alters functional vesicle cargo.

Authors

Robert Zarnowski, Jeniel E Nett, Tim S Bugni, David Andes

Published in

Antimicrobial agents and chemotherapy. Pages e0055826. Jun 22, 2026. Epub Jun 22, 2026.

Abstract

Candida biofilms produce an extracellular matrix that sequesters antifungals, allowing cells to proliferate despite otherwise therapeutic concentrations. A prior study found turbinmicin to inhibit the release of the extracellular vesicles (EVs) required for matrix delivery and drug resistance. Here, we show that turbinmicin also alters the cargo loaded into EVs, decreasing the relative abundance of proteins that drive production of the drug-sequestering matrix. Turbinmicin displays a new dual antifungal action, disrupting both EV quantity and cargo.

PMID:
42363835
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

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