Controlled Formation and Unusual Reactivity of Cyanohexatriyne (HC₇N), a Synthetically Challenging Interstellar Cyanopolyyne.

Authors

Léa Lefrançois, Mano Cremer, Thierry Roisnel, Jean-Claude Guillemin, Yann Trolez

Published in

Chemistry (Weinheim an der Bergstrasse, Germany). Pages e71321. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

Cyanohexatriyne (HC₇N), a highly unstable member of the interstellar cyanopolyyne family, has long resisted synthetic access. We report the first reproducible formation of HC₇N at the milligram scale, enabled by a cobalt-alkyne masking strategy that circumvents the intrinsic instability of extended sp-carbon chains bearing a terminal nitrile. This approach overcomes the limitations of classical C_sp-C_sp coupling methods and provides enough material for chemical investigation. The formed HC₇N was characterized in solution and shown to undergo a rapid and stereoselective conjugate addition with diethylamine to the terminal C≡C triple bond.

PMID:
42364084
Bibliographic data and abstract were imported from PubMed on 27 Jun 2026.

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