Chronic suppression of a multidrug-resistant Pseudomonas aeruginosa in prosthetic joint infection using personalized bacteriophage treatment.

Authors

Rekha Arya, Dongzhu Ma, Jewelia J Rempuszewski, Nadine M Sadaka, Andrew J Frear, Beth Knapick, Dana M Parker, Vaughn S Cooper, Daria Van Tyne, Neel B Shah, James B Doub, Umit Akbey, Joseph Fackler, Subhendu Basu, Arkadiy Garber, Erin M Nawrocki, Kenneth L Urish

Published in

Nature communications. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

Multidrug resistant (MDR) bacterial infections without antibiotic options are a public health emergency. Infections associated with medical implants serve as an example. Conventional antibiotics have limited ability to eradicate these infections as they are associated with antibiotic-tolerant biofilms. Here, we report the use of bacteriophage therapy for the treatment of a MDR, non-operable Pseudomonas aeruginosa periprosthetic joint infection that had failed multiple antibiotic and surgical interventions. Treatment with intermittent bacteriophage therapy alone without antibiotics over a 2 year time period resulted in clinical resolution of the infection, but not microbiological eradication. Bacteriophage therapy established this control, in part, by altering virulence as defined by disease severity and symptoms and disrupting biofilm. Whole genome sequencing demonstrated the continued presence of bacteriophage during treatment. This provides preliminary evidence that bacteriophage therapy can be used to treat MDR infections in salvage cases when surgical and antibiotic options do not exist.

PMID:
42364990
Bibliographic data and abstract were imported from PubMed on 28 Jun 2026.

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