Comparative hemostatic efficacy of oxidized regenerated cellulose powder and fibrin glue in a rat model of induced liver parenchymal hemorrhage.

Authors

Berkan Acar, Abdulkadir Çelik, Arslan Hasan Kocamaz, Ömer Kişi, Alper Varman, Selman Alkan, Sıdıka Fındık, İbrahim Kılınç, Mustafa Şentürk, Tevfik Küçükkartallar

Published in

BMC research notes. Jun 27, 2026. Epub Jun 27, 2026.

Abstract

The objective of this study is to compare the hemostatic efficacy of oxidised regenerated cellulose powder (Surgicel^® Powder) and fibrin glue (Tisseel^®) in a rat model of liver parenchymal haemorrhage, and to evaluate their effects on tissue healing.
Preoperative haemoglobin and haematocrit values were comparable among the groups (p > 0.05). At 24 h, postoperative haemoglobin and haematocrit values differed significantly among the three groups (p = 0.045 and p = 0.042, respectively), with lower values in the saline-compression control group and relatively preserved values in the Surgicel^® Powder and Tisseel^® groups. However, no statistically significant difference was identified between the two active treatment groups. Histopathological evaluation revealed no statistically significant between-group differences in necrosis, inflammation, fibrosis, haemorrhage, or granulation tissue formation (p > 0.05).

PMID:
42365352
Bibliographic data and abstract were imported from PubMed on 28 Jun 2026.

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